Previously announced match-ups of John Howard vs. Dennis Hallman and Kenny Florian vs. Clay Guida were moved to The Ultimate Fighter: Heavyweights Finale and UFC 107 respectively.
MMAWeekly.com had reported that Tom Lawlor would fight on the card but he has been moved to UFC Fight Night: Maynard vs. Diaz.
Tito Ortiz was originally scheduled to fight Mark Coleman. However, on October 5, 2009, Ortiz reported that the fight was now off, and it later became known that Coleman was suffering from a knee injury. UFC confirmed that Forrest Griffin would step in to face Ortiz.
Jon Fitch was originally set to fight Ricardo Almeida but Almeida was forced off the card with a knee injury. Fitch was announced to fight Thiago Alves at UFC 107, but Alves was forced to pull out due to an injury during training. Fitch is still on the UFC 107 card and will now be fighting Mike Pierce.
On October 26, UFC Heavyweight Champion Brock Lesnar pulled out of his fight against Shane Carwin due to an illness (mononucleosis) that has kept him from training for several weeks.While resting in Canada, he collapsed and was hospitalized, and was found to also have a serious intestinal disorder that may possibly end his career. The UFC therefore had the Ortiz v. Griffin fight headline the UFC 106 card.
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